What is U-500 insulin ? U-500 is regular insulin that is available in United States since the year 1952. However, recently doctors have started prescribing this medicine commonly to patients who require high doses of insulin in order to control their blood sugar level. This medicine is prescribed for patients who are facing increasing obesity along with type 2 diabetes and their bodies have become resistant to insulin. This resistance to insulin necessitates the need of insulin of more than 200 units/day. At present, several health care professionals are unaware of this concentrated insulin formulation. U-500 has pharmacodynamic and pharmacokinetic profile which makes it different from U-100 human insulins as well as analogues. There is no specific clinical trial to prove the efficiency of U-500 insulin. However, there is an eight case series that has been published. It reports infrequent or rare occurrence of hypoglycaemia with use of U-500 insulin. The medication errors that are linked with the use of U-500 insulin are generally due to dispensing and administrating errors. The pharmacists that prescribe U-500 should be aware of complex issues associated with its correct prescribing and dispensing. Patients should be properly guided about its use to minimize the errors related to its administration and dosage. U-500 Insulin – Insulin [...]